## Abstract For Abstract see ChemInform Abstract in Full Text.
Synthesis of new derivatives of 5,6,7,8-tetrahydro-1,6-naphthyridines and their pharmacological properties
β Scribed by S. Z. Vatsadze; M. L. Kostochka; V. P. Lezina; V. G. Vinokurov; P. M. Klodt; N. V. Zyk
- Publisher
- Springer
- Year
- 2005
- Tongue
- English
- Weight
- 266 KB
- Volume
- 54
- Category
- Article
- ISSN
- 1573-9171
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An expeditious and concise synthesis of 3-(difluoromethoxy)-5,6,7,8-tetrahydro-1,6-naphthyridine and 3-(trifluoromethoxy)-5,6,7,8-tetrahydro-1,6-naphthyridines is described. Starting from N-benzyl piperidone, the key intermediates leading to these two biologically desirable synthones were rapidly as
## Abstract A new access to 5βphenylβ5,6,7,8βtetrahydroβ1,6βnaphthyridines **25aβ28a** (n=1) and 5βphenylβ6,7,8,9βtetrahydroβ5__H__βpyrido[3,2β__c__]azepines **25bβ28b** (n=2) has been developed by first preparing the functional pyridine moiety followed by intramolecular cyclization forming the par