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Lewis Base Catalyzed Aldol Reaction of Trimethylsilyl Enolates with Aldehydes.

✍ Scribed by Teruaki Mukaiyama; Hidehiko Fujisawa; Takashi Nakagawa


Publisher
John Wiley and Sons
Year
2003
Weight
247 KB
Volume
34
Category
Article
ISSN
0931-7597

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## Abstract Aldol reactions between trimethylsilyl ketene acetals and aldehydes by using a catalytic amount of alkoxide anion proceeded smoothly to afford the corresponding aldols in DMF, indicating that the initially‐formed aldolate anion effectively worked to catalyze the reaction. The β€œproduct‐c