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Lewis Acid Catalyzed Geminal Acylation Reaction of Ketones with 1,2-Bis[(trimethylsilyl)oxy]cyclobutene: Direct Formation of 2,2-Disubstituted 1,3-Cyclopentanediones

โœ Scribed by Jenkins, Tracy J.; Burnell, D. Jean


Book ID
121420178
Publisher
American Chemical Society
Year
1994
Tongue
English
Weight
867 KB
Volume
59
Category
Article
ISSN
0022-3263

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The BF 3 โ€ขEt 2 O-Catalyzed Reaction of 1,2-Bis[(trimethylsilyl)oxy]cyclobutene and Analogues with Aromatic Ketones. -Aromatic ketones (I) and (V) undergo geminal acylation with cyclobutene (II) and its methylated analogues (VIII). Subsequent rearrangement, especially during aqueous work-up, results