Levodopa stability in solution: Time course, environmental effects, and practical recommendations for clinical use

✍ Scribed by Dr. Eric J. Pappert; Colleen Buhrfiend; Jack W. Lipton; Paul M. Carvey; Glenn T. Stebbins; Christopher G. Goetz

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 252 KB
• Volume: 11
• Category: Article
• ISSN: 0885-3185
• DOI: 10.1002/mds.870110106

✦ Synopsis

We defined the temporal stability characteristics of levodopdcarbidopa (LD/CD) solution, and determined the effects of temperature, ascorbate, and light on LD stability over 7 days. At room temperature and without ascorbate, LD levels significantly declined by 48 h. Ascorbate prolonged stability to 72 h. Refrigeration and freezing prevented a significant decline in LD levels for the full 7 days. Light or darkness had no effect on stability. LDlCD solution, if made daily, requires no special handling and longer stability is maintained with ascorbate, refrigeration, or freezing.