Pharmaceutical-mediated inactivation of
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G. Wei Xu; Joe S. Mymryk; J. Gregory Cairncross
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Article
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2005
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John Wiley and Sons
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French
β 261 KB
## Abstract PifithrinβΞ± (PFTΞ±) is a small molecule inhibitor of p53. By reversibly blocking apoptosis in response to DNA damage, PFTΞ± protects normal cells from lethal doses of Ξ³βradiation (Komarov __et al.__, Science, 1999;285:1733β7). We examined the effect of PFTΞ± on the chemosensitivity of a hu