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Levetiracetam enhances p53-mediated MGMT inhibition and sensitizes glioblastoma cells to temozolomide

✍ Scribed by Bobustuc, G. C.; Baker, C. H.; Limaye, A.; Jenkins, W. D.; Pearl, G.; Avgeropoulos, N. G.; Konduri, S. D.


Book ID
117990966
Publisher
Duke University Press
Year
2010
Tongue
English
Weight
528 KB
Volume
12
Category
Article
ISSN
1522-8517

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## Abstract Pifithrin‐α (PFTΞ±) is a small molecule inhibitor of p53. By reversibly blocking apoptosis in response to DNA damage, PFTΞ± protects normal cells from lethal doses of γ‐radiation (Komarov __et al.__, Science, 1999;285:1733–7). We examined the effect of PFTΞ± on the chemosensitivity of a hu