Pharmaceutical-mediated inactivation of
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G. Wei Xu; Joe S. Mymryk; J. Gregory Cairncross
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Article
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2005
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John Wiley and Sons
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French
⚖ 261 KB
## Abstract Pifithrin‐α (PFTα) is a small molecule inhibitor of p53. By reversibly blocking apoptosis in response to DNA damage, PFTα protects normal cells from lethal doses of γ‐radiation (Komarov __et al.__, Science, 1999;285:1733–7). We examined the effect of PFTα on the chemosensitivity of a hu