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Levels of Three Hydrolases in Rheumatoid and Regenerated Synovium

✍ Scribed by Dr. J. L. Granda; C. S. Ranawat; A. S. Posner

Publisher
John Wiley and Sons
Year
1971
Tongue
English
Weight
405 KB
Volume
14
Category
Article
ISSN
0004-3591

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πŸ“œ SIMILAR VOLUMES

Immunoelectron microscopic demonstration
Immunoelectron microscopic demonstration of prostaglandin e in rheumatoid synovium
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The presence of prostaglandin E (PGE) in rheumatoid synovium was investigated by immunoelectron microscopy; horseradish peroxidase-conjugated antibodies were used to stain the PGE. PGE was stained mainly in cytoplasmic granules of macrophage-like cells of the rheumatoid synovium. These granules had

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Objective. Microsomal prostaglandin E synthase 1 (mPGES-1) catalyzes the formation of PGE 2 from cyclooxygenase-derived PGH 2 . Microsomal PGES-1 is induced by proinflammatory cytokines and is strongly linked to conditions that result in high PGE 2 biosynthesis. PGE 2 contributes to the pathogenesis