β Scribed by Joad L. Ascensao; Martin M. Oken; Stephen L. Ewing; Robert J. Goldberg; Manuel E. Kaplan
No coin nor oath required. For personal study only.
In a retrospective study of 105 patients with non-small cell lung cancer during a 5-year period, 43 had leukocytosis. In 19 of the 43 patients, no clear cut etiology for the leukocytosis was apparent and it was attributed to the tumor itself. In these 19 patients, absolute neutrophilia was detected in 13, eosinophilia was present in three, and eleven exhibited concomitant thrombocytosis. Tumor-associated leukocytosis occurred predominantly, and eosinophilia exclusively, in patients with large cell pulmonary neoplasms. These results suggest an unusual myeloproliferative stimulus in this type of cancer. It may result from tumor cell production of hemopoietic growth factors such as granulocyte-macrophage colony-stimulating activity; however, additional studies are needed to elucidate the underlying mechanism(s), and to determine whether this is a peculiar characteristic of the cells that comprise large cell undifferentiated carcinoma of the lung.
Cancer 60:903-905,1987.
L or during the course of the disease.'-3 It may be caused by one or more factors such as concomitant infection, tumor necrosis, administration of steroids, and/ or endocrine production of granulopoietic molecules such as the granulocyte-macrophage colony-stimulating activity (CSA).'s4 We previously reported on the occurrence of eosinophilia in a patient with large cell undifferentiated carcinoma, presumably due to production of CSA by the tumor cells.5 In this study, we analyze the occurrence of leukocytosis, neutrophilia, and eosinophilia in a cohort of patients with lung cancer. Our findings suggest that these phenomena occur more frequently in patients with large cell lung cancer.
Methods A retrospective analysis was conducted of the medical records of 105 patients diagnosed as having nonsmall cell lung cancer at the Minneapolis Veterans Administration Medical Center (MVAH) between June
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