Leukemia in a black child with Bloom's syndrome. Somatic recombination as a possible mechanism for neoplasia

Brainstem glioma after radiation therapy

Brainstem glioma after radiation therapy for acute myeloblastic leukemia in a child with down syndrome. Possible pathogenetic mechanisms

✍ David Zagzag; Douglas C. Miller; Joan Cangiarella; Jeffrey C. Allen; M. Alba Gre 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 822 KB

A 13-year-old boy with Down syndrome (DS) had a brainstem glioma confirmed at autopsy, 10 years after receiving prophylactic cranial irradiation for acute myeloblastic leukemia. There is no clear association of brain tumors with DS; despite a reported link between leukemia and glioma, a causal assoc