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Leptin is a potent stimulator of bone growth in ob/ob mice

✍ Scribed by Claire M. Steppan; D.Todd Crawford; Kristen L. Chidsey-Frink; HuaZhu Ke; Andrew G. Swick


Book ID
117348374
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
244 KB
Volume
92
Category
Article
ISSN
0167-0115

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## Abstract Leptin is the __LEP__ (__ob__) gene product secreted by adipocytes. We previously reported that leptin decreases renal expression of the 25‐hydroxyvitamin D~3~ 1α‐hydroxylase (__CYP27B1__) gene through the leptin receptor (ObRb) by indirectly acting on the proximal tubules. This study f