## Abstract Both central and peripheral leptin administrations reduce body weight, food intake, and adiposity in __ob/ob__ mice. In this study we compared effects of intracerebroventricular (ICV) and subcutaneous (SC) administration of leptin on bone metabolism in the appendicular and axial skeleto
Leptin Treatment Induces Loss of Bone Marrow Adipocytes and Increases Bone Formation in Leptin-Deficient ob/ob Mice
β Scribed by Mark W Hamrick; Mary Anne Della-Fera; Yang-Ho Choi; Catherine Pennington; Diane Hartzell; Clifton A Baile
- Book ID
- 111485239
- Publisher
- American Society for Bone and Mineral Research
- Year
- 2005
- Tongue
- English
- Weight
- 881 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0884-0431
No coin nor oath required. For personal study only.
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## Abstract Leptin is the __LEP__ (__ob__) gene product secreted by adipocytes. We previously reported that leptin decreases renal expression of the 25βhydroxyvitamin D~3~ 1Ξ±βhydroxylase (__CYP27B1__) gene through the leptin receptor (ObRb) by indirectly acting on the proximal tubules. This study f
## Abstract Leptin is a hormone secreted by adipocytes that is implicated in the regulation of bone density. Serum leptin levels are decreased in rodent models of type 1 (T1β) diabetes and in diabetic patients. Whether leptin mediates diabetic bone changes is unclear. Therefore, we treated control