Matrilysin is a member of the matrix metalloproteinase gene family. which is believed to play an important role in tumor invasion and metastasis. We examined the effects of over-and under-expression of matrilysin on the ability of colon cancer cells to migrate across an artificial membrane in vitro.
Leptin induces cell invasion and the upregulation of matrilysin in human colon cancer cells
โ Scribed by Lin, Meng-Chiu; Tsai, Shu-Yao; Wang, Fu-Yu; Liu, Fu-Hsuan; Syu, Jia-Ning; Tang, Feng-Yao
- Book ID
- 122046399
- Publisher
- EDP Sciences
- Year
- 2013
- Tongue
- English
- Weight
- 697 KB
- Volume
- 3
- Category
- Article
- ISSN
- 2211-8020
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## Abstract Leptin serum levels are about 5 times higher in obese people than in normal individuals. We aimed at investigating the signaling pathways induced by leptin in the human colonic cell lines LS174T and HM7. Both cells expressed the leptin transmembrane Obโreceptor. Leptin activated the mit
## Abstract Matrilysin, which is a member of the matrix metalloproteinase family and is implicated in colon cancer invasion, is expressed in human colon adenocarcinomaโderived SW1116 cells. We investigated the effect of ฮฑโdifluoromethylornithine (DFMO) on matrilysin expression in this cell line bec