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Suppression of matrilysin inhibits colon cancer cell invasion in vitro

✍ Scribed by Hiroyuki Yamamoto; Fumio Itoh; Yuji Hinod; Kohzoh Imai

Publisher
John Wiley and Sons
Year
1995
Tongue
French
Weight
853 KB
Volume
61
Category
Article
ISSN
0020-7136

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✦ Synopsis

Matrilysin is a member of the matrix metalloproteinase gene family. which is believed to play an important role in tumor invasion and metastasis. We examined the effects of over-and under-expression of matrilysin on the ability of colon cancer cells to migrate across an artificial membrane in vitro. Introduction of matrilysin caused colon cancer cells to become more invasive as assessed by an in vitro invasion assay. In contrast, expression of matrilysin was down-regulated by all transretinoic acid or by introduction of anti-sense matrilysin in BM3 14 colon cancer cells. This down-regulation caused these

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