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Leptin increases motility and integrin up-regulation in human prostate cancer cells

✍ Scribed by Chih-Yang Huang; Hsin-Shan Yu; Tung-Yuan Lai; Yu-Lan Yeh; Cheng-Chuan Su; His-Hsien Hsu; Fuu-Jen Tsai; Chang-Hai Tsai; Hsi-Chin Wu; Chih-Hsin Tang

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
360 KB
Volume
226
Category
Article
ISSN
0021-9541

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✦ Synopsis

Abstract

Prostate cancer is the most commonly diagnosed malignancy in men and shows a predilection for metastasis to distant organs. Leptin, an adipocyte‐derived cytokine that is closely associated with obesity, has recently been shown to be involved in carcinogenesis and cancer progression. The aim of this study was to investigate whether leptin is associated with the motility of prostate cancer cells. We found that leptin increased the migration of human prostate cancer cells and expression of αvβ3 integrin on these cells. Leptin‐mediated migration and increased integrin expression were attenuated by OBRl receptor antisense oligonucleotide (ODN). Activation of insulin receptor substrate (IRS‐1), phosphatidylinositol 3‐kinase (PI3K), Akt, and NF‐κB pathways after leptin treatment was demonstrated. Furthermore, leptin‐induced integrin expression and migration activity were inhibited by specific inhibitors; small interfering RNAs (siRNAs); and mutants of the IRS‐1, PI3K, Akt, and NF‐κB cascades. Therefore, this study shows that leptin stimulates the migration of human prostate cancer cells, one of the mechanisms underlying leptin‐directed migration was transcriptional up‐regulation of αvβ3 integrin expression through the OBR1/IRS‐1/PI3K/Akt/NF‐κB signal transduction pathway. J. Cell. Physiol. 226: 1274–1282, 2011. © 2010 Wiley‐Liss, Inc.

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