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Leptin and high glucose induces cell proliferation in drug sensitive human breast cancer cells (MCF7) but not in multidrug-resistant cells (MCF7/ADR): Possible involvement of the changes of PKC-α expression treated with glucose and leptin

✍ Scribed by Mie Okumura; Mayumi Yamamoto; Hiroya Sakuma; Toshihiro Kojima; Keigo Yasuda; Denise R Cooper

Book ID: 117370080
Publisher: Elsevier Science
Year: 2000
Tongue: English
Weight: 144 KB
Volume: 50
Category: Article
ISSN: 0168-8227
DOI: 10.1016/s0168-8227(00)81984-1

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## Glucose concentration may be an important factor in breast cancer cell proliferation because the prevalence of breast cancer is high in diabetic patients. To determine the role of protein kinase C (PKC)-␤II in regulating MCF-7 cell proliferation at different glucose concentrations, the effects o