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Lenalidomide treatment of chronic lymphocytic leukaemia patients reduces regulatory T cells and induces Th17 T helper cells

✍ Scribed by Irina Idler; Krzysztof Giannopoulos; Thorsten Zenz; Nupur Bhattacharya; Maria Nothing; Hartmut Döhner; Stephan Stilgenbauer; Daniel Mertens

Book ID: 108676612
Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 142 KB
Volume: 148
Category: Article
ISSN: 0007-1048
DOI: 10.1111/j.1365-2141.2009.08014.x

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The combination of cytotoxic treatment with strategies for immune activation represents an attractive strategy for tumour therapy. Following reduction of high tumour burden by effective cytotoxic agents, two major immune-stimulating approaches are being pursued. First, innate immunity can be activat