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Lefty Proteins Are Long-Range Inhibitors of Squint-Mediated Nodal Signaling

✍ Scribed by Yu Chen; Alexander F Schier

Book ID: 114319529
Publisher: Elsevier Science
Year: 2002
Tongue: English
Weight: 224 KB
Volume: 12
Category: Article
ISSN: 0960-9822
DOI: 10.1016/s0960-9822(02)01362-3

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Mammalian lefty and zebrafish antivin form a subgroup of the TGF beta superfamily. We report that mouse mutants for lefty2 have an expanded primitive streak and form excess mesoderm, a phenotype opposite to that of mutants for the TGF beta gene nodal. Analogously, overexpression of Antivin or Lefty2