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Mouse Lefty2 and Zebrafish Antivin Are Feedback Inhibitors of Nodal Signaling during Vertebrate Gastrulation

✍ Scribed by Chikara Meno; Kira Gritsman; Sachiko Ohishi; Yasuhisa Ohfuji; Elizabeth Heckscher; Kyoko Mochida; Akihiko Shimono; Hisato Kondoh; William S Talbot; Elizabeth J Robertson; Alexander F Schier; Hiroshi Hamada

Book ID: 117736297
Publisher: Elsevier Science
Year: 1999
Tongue: English
Weight: 476 KB
Volume: 4
Category: Article
ISSN: 1097-2765
DOI: 10.1016/s1097-2765(00)80331-7

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Mouse Lefty2 and Zebrafish Antivin Are F

Mouse Lefty2 and Zebrafish Antivin Are Feedback Inhibitors of Nodal Signaling during Vertebrate Gastrulation

✍ Chikara Meno; Kira Gritsman; Sachiko Ohishi; Yasuhisa Ohfuji; Elizabeth Hecksche 📂 Article 📅 1999 🏛 Elsevier Science 🌐 English ⚖ 476 KB

Mammalian lefty and zebrafish antivin form a subgroup of the TGF beta superfamily. We report that mouse mutants for lefty2 have an expanded primitive streak and form excess mesoderm, a phenotype opposite to that of mutants for the TGF beta gene nodal. Analogously, overexpression of Antivin or Lefty2