Left–right axis malformations in man and mouse
✍ Scribed by Brett Casey; Brian P Hackett
- Book ID
- 117654667
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 103 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0959-437X
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Normal left-right asymmetry is highly conserved among vertebrates. Errors in the proper patterning of this axis are believed to lead to congenital anomalies of the heart and abdominal viscera, often with profound clinical consequences. We review briefly the nature of potential signals and signaling
Targeted disruption of the mouse activin receptor type IIB gene (Acvr2b) results in abnormal left-right (LR) axis development among Acvr2b-/- homozygotes [Oh and Li, 1997: Genes Dev 11:1812-1826]. The resulting malformations include atrial and ventricular septal defects, right-sided morphology of th