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Lectin agglutinability of non-neoplastic and neoplastic human lymphoid cells in vitro

✍ Scribed by Bengt Glimelius; Kenneth Nilsson; Jan Pontén

Publisher
John Wiley and Sons
Year
1975
Tongue
French
Weight
609 KB
Volume
15
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Agglutination by two lectins, Concanavalin A (Con A) and Ricinus communis agglutinin (RCA), has been investigated in a human lymphoid cell system. The main conclusions of this study are: (1) no systematic correlation exists between the neoplastic state and sensitivity to Con A or RCA; (2) cells of neoplastic lines vary unsystematically in their surface properties as evaluated by Con A agglutination, with the possible exception that presence of Epstein‐Barr virus (EBV) is associated with a high degree of agglutination and (3) cells of diploid lymphoblastoid lines and phytohemagglutinin (PHA)‐stimulated lymphocytes agglutinate similarly and significantly better than unstimulated T‐ or B‐lymphocytes. The relatively simple Con A agglutination assay can be used as an adjunct in classification of human lymphoid cell lines.

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