โ Scribed by P. A. C. Eagle
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
N-(2-Hydroxyethyl)-4-nitrobenzenesulfonamide ( 1 ) reacts when heated with an excess of dilute sodium hydroxide solution to give 2-hydroxyethyl-4-nitrophenylamine (2). O z N ~S 0 2 N H -C H z C H 2 0 H -+ 2 NaOH ( 1) (Z), 96% Starting material Rearrangement prod! M.P. ("C
The t i t b compound I rcacts with alkyl (or phenyl) isocyanates 2 in a molar ratio of 1 : t to give the N-monoadducts 3 which cyclim readily to yield the 6-aminouracils 4, whereas in a molar ratio of 1 : 1 mainly N.N-bisadducts 6 and. in LWO cases, small amounts of C.N-bisaadductr 5 are lormcd. The
Oxidation of Isothiocyanates to Isocyanates Using Dimethyldioxirane; Relevance to Biological Activity of Isothiocyanates. -Oxidation of both alkyl and aryl isothiocyanates with dimethyldioxirane affords efficiently the corresponding isocyanates (II), which are trapped with iPrNH 2 to furnish the ur