𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Lead intoxication: Histological and oxidative damage in rat cerebrum and cerebellum

✍ Scribed by Pardeep Sidhu; Bimla Nehru

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
141 KB
Volume
17
Category
Article
ISSN
0896-548X

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The present experiment was designed to study the neurotoxic consequences of lead exposure on antioxidant enzymes like glutathione, glutathione peroxidase, super oxide dismustase, and catalase along with structural changes both in cerebrum as well as cerebellum. Lead was administrated orally in the doses of 50 mg/kg for a period of 8 weeks and study was performed at the end of exposure. Decrease in the concentration of all the antioxidant enzymes was observed, and after lead treatment, transverse sections of cerebrum showed degeneration of neurons. Disruption of normal arrangement of cell layers was seen. Cells were bigger in size with large vascular spaces around them. Lead treatment for 8 weeks also was enough to disrupt the normal arrangement of cellular layer of cerebellum. Large spaces in between purkinje cell layer and granular layer were seen. J. Trace Elem. Exp. Med. 17:45–53, 2004. Β© 2004 Wiley‐Liss, Inc.

πŸ“œ SIMILAR VOLUMES

Synthesis of arachidonoyl coenzyme a and
Synthesis of arachidonoyl coenzyme a and docosahexaenoyl coenzyme a in synaptic plasma membranes of cerebrum and microsomes of cerebrum, cerebellum, and brain stem of rat brain
✍ T.S. Reddy; Dr. N.G. Bazan πŸ“‚ Article πŸ“… 1985 πŸ› John Wiley and Sons 🌐 English βš– 638 KB

Synthesis of arachidonoyl CoA and docosahexaenoyl CoA in homogenates and microsomes from cerebrum, cerebellum, and brain stem and in synaptic plasma membranes from cerebrum of control rats and rats undergoing bicuculline-induced status epilepticus were studied. Arachidonoyl CoA synthesis was 3-5 tim

Changes in renal function and oxidative
Changes in renal function and oxidative damage in methamphetamine-treated rat
✍ Itsuo Tokunaga; Shin-ichi Kubo; Akiko Ishigami; Takako Gotohda; Osamu Kitamura πŸ“‚ Article πŸ“… 2006 πŸ› Elsevier Science 🌐 English βš– 222 KB

In this study, we observed renal damage and peroxidative injury as the acute or sub-acute effect of methamphetamine (MA) to determine whether MA intoxication can be diagnosed from immunohistochemical changes in the kidney. In addition, renal function was investigated in relation to the immunohistoch

Lead-induced alterations of apoptosis an
Lead-induced alterations of apoptosis and neurotrophic factor mRNA in the developing rat cortex, hippocampus, and cerebellum
✍ Shirley L. Chao; Jason M. Moss; G. Jean Harry πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 367 KB

## Abstract Previous reports have recently shown the prototypic neurotoxicant, lead, to induce apoptosis in the brains of developing organisms. In the current study, timed‐pregnant rats were exposed to lead acetate (0.2% in the drinking water) 24 h following birth at postnatal day 1 (PND 1). Dams a

Melatonin reduces protein and lipid oxid
Melatonin reduces protein and lipid oxidative damage induced by homocysteine in rat brain homogenates
✍ Santiago Ortega-GutiΓ©rrez; Lorena Fuentes-Broto; JoaquΓ­n J. GarcΓ­a; Marta LΓ³pez- πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 149 KB πŸ‘ 1 views

## Abstract Numerous data indicate that hyperhomocysteinemia is a risk factor for cardio‐ and cerebrovascular diseases. At least in part, homocysteine (HCY) impairs cerebrovascular function because it generates large numbers of free radicals. Since melatonin is a well‐known antioxidant, which reduc