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Lead-induced leukocytosis in female mice

✍ Scribed by G. R. Hogan; D. P. Adams

Publisher
Springer-Verlag
Year
1979
Tongue
English
Weight
287 KB
Volume
41
Category
Article
ISSN
0340-5761

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✦ Synopsis

Lead acetate was shown to stimulate a striking leukocytosis in young adult female mice. The effect was manifest 4 days after lead injection and continued throughout the following 4 days. At the higher treatment level, lead induced an increase of 300% for both monocytes and neutrophils. The leukocytosis was due primarily to the elevated levels of neutrophils as suggested by a decrease in the ratios of peripheral agranulocytes to granulocytes. No differences from normal leukocyte cytology were observed in blood samples collected from animals receiving lead.

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