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LC/MS/MS Method for the Quantitation of trans -2-Hexenal-Derived Exocyclic 1, N 2 -Propanodeoxyguanosine in DNA

✍ Scribed by Stout, Matthew D.; Jeong, Yo-Chan; Boysen, Gunnar; Li, Yutai; Sangaiah, Ramiah; Ball, Louise M.; Gold, Avram; Swenberg, James A.


Book ID
127207367
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
165 KB
Volume
19
Category
Article
ISSN
0893-228X

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## Abstract 6‐oxo‐PGF~1Ξ±~ and TXB~2~ are the metabolites of the prostanglandin PGI~2~ and of the thromboxane TXA~2~, respectively. PGI~2~ and TXA~2~ are arachidonic acid‐derived compounds which regulate the blood hemostasis. Their quick metabolism leads to the 6‐oxo‐PGF~1Ξ±~ and TXB~2~ metabolites i