LC–MS–MS identification of albendazole and flubendazole metabolites formedex vivobyHaemonchus contortus
✍ Scribed by Viktor Cvilink; Lenka Skálová; Barbora Szotáková; Jiří Lamka; Risto Kostiainen; Raimo A. Ketola
- Publisher
- Springer
- Year
- 2008
- Tongue
- English
- Weight
- 224 KB
- Volume
- 391
- Category
- Article
- ISSN
- 1618-2650
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## ABSTRACT The development and validation of an LC‐MS/MS method for the simultaneous determination of albendazole metabolites (albendazole sulfoxide and albendazole sulfone) in human plasma are described. Samples of 200 μL were extracted with ether–dichloromethane–chloroform (60:30:10, v/v/v). The
## Abstract For rapid screening of natural products from __Actinomycetes__, a combination of on‐line couplings LC–NMR, LC–DAD–MS and HPLC–PDA, as well as MALDI–TOF–MS is particularly suitable. Simultaneous use of these coupling techniques provides considerable advantages for the rapid identificatio