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LC-MS/MS method for the simultaneous quantification of artesunate and its metabolites dihydroartemisinin and dihydroartemisinin glucuronide in human plasma

✍ Scribed by Geditz, Mirjam C. K.; Heinkele, Georg; Ahmed, Asma; Kremsner, Peter G.; Kerb, Reinhold; Schwab, Matthias; Hofmann, Ute

Book ID
125342004
Publisher
Springer
Year
2014
Tongue
English
Weight
586 KB
Volume
406
Category
Article
ISSN
1618-2650

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Development and validation of a liquid chromatography and ion spray tandem mass spectrometry method for the quantification of artesunate, artemether and their major metabolites dihydroartemisinin and dihydroartemisinin-glucuronide in sheep plasma
✍ Urs Duthaler; Jennifer Keiser; JΓΆrg Huwyler πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons 🌐 English βš– 228 KB

## Abstract Recently, promising fasciocidal activities of artesunate and artemether were described in rats and sheep. Therefore, a liquid chromatography–tandem mass spectrometry (LC–MS/MS) method was developed to quantify artesunate, artemether and their metabolites dihydroartemisinin and dihydroar