LC-MS in Drug Bioanalysis || Method Development, Validation, and Sample Analysis for Regulated Quantitative Bioanalysis Using LC-MS/MS

✍ Scribed by Xu, Q. Alan; Madden, Timothy L.

• Book ID: 118197331
• Publisher: Springer US
• Year: 2012
• Tongue: English
• Weight: 1010 KB
• Edition: 2012
• Category: Article
• ISBN: 1461438284
• DOI: 10.1007/978-1-4614-3828-1_2

✦ Synopsis

Clinical pharmacology plays an important role in today’s medicine. Due to the high sensitivity, selectivity, and affordability of a mass spectrometer (MS), the high performance liquid chromatography – mass spectrometry (LC-MS) analytical technique is widely used in the determination of drugs in human biological matrixes for clinical pharmacology. Specifically, LC-MS is used to analyze: anticancer drugs antidementia drugs antidepressant drugs antiepileptic drugs antifundal drug antimicrobial drugs antipsychotic drugs antiretroviral drugs anxiolytic/hypnotic drugs cardiac drugs drugs for addiction immunosuppressant drugs mood stabilizer drugs This book will primarily cover the various methods of validation for LC-MS techniques and applications used in modern clinical pharmacology.