LC-MS in Drug Analysis: Methods and Protocols

✍ Scribed by Loralie J Langman; Christine L H Snozek

• Publisher: Humana Press
• Year: 2018
• Tongue: English
• Leaves: 270
• Edition: Hardcover
• Category: Library

✦ Synopsis

This second edition provides detailed LC-MS(/MS) procedures for the analysis of compounds of clinical and toxicological significance. Chapters detail new and updated methods for analyzing drugs focusing on advances in technology, alternate matrices, and rapidly-changing classes of drugs of abuse, compounds pertinent to toxicology, and therapeutic agents. Written in the highly successfulMethods in Molecular Biologyseries format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Authoritative and cutting-edge,LC-MS in Drug Analysis: Methods and Protocols, Second Editionaims to ensure successful reults in the further study of this vital field.

✦ Table of Contents

Front Matter ....Pages i-x
An Introduction to Drug Testing: The Expanding Role of Mass Spectrometry (Christine L. H. Snozek, Loralie J. Langman, Steven W. Cotten)....Pages 1-10
Quantification of Eight Cannabinoids Including Cannabidiol in Human Urine Via Liquid Chromatography Tandem Mass Spectrometry (Karl B. Scheidweiler, Allan J. Barnes)....Pages 11-22
Analysis of Benzodiazepines for Drug-Facilitated Assaults and Abuse Settings (Urine) (Olaf H. Drummer, Matthew Di Rago, Dimitri Gerostamoulos)....Pages 23-39
Targeted Opioid Screening Assay for Pain Management Using High-Resolution Mass Spectrometry (Darlington Danso, Loralie J. Langman, Paul J. Jannetto)....Pages 41-50
Measurement of Buprenorphine and Norbuprenorphine in Urine (Andrea R. Terrell, Vipin Adhlakha, Poluru Reddy)....Pages 51-59
Quantitation of Tapentadol by Liquid Chromatography: Tandem Mass Spectrometry (Graham R. Jones, Russell P. Handy)....Pages 61-65
Therapeutic Drug Monitoring of Lacosamide by LC-MS/MS (He Sarina Yang, Leslie Edinboro)....Pages 67-73
LC-MS/MS Method for the Quantification of the Leflunomide Metabolite, Teriflunomide, in Human Serum/Plasma (Geoffrey S. Rule, Alan L. Rockwood, Kamisha L. Johnson-Davis)....Pages 75-83
Analysis of Tryptic Peptides from Therapeutic Monoclonal Antibodies Using LC-MS/MS (Maria Alice V. Willrich)....Pages 85-99
Quantification of Methotrexate in Human Serum and Plasma by Liquid Chromatography Tandem Mass Spectrometry (Gabrielle N. Winston-McPherson, Michael Schmeling, Andrew N. Hoofnagle)....Pages 101-110
Simultaneous Determination of Tacrolimus and Cyclosporine A in Whole Blood by Ultrafast LC-MS/MS (Matthew W. Bjergum, Paul J. Jannetto, Loralie J. Langman)....Pages 111-118
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) Method to Quantify Gabapentin and Pregabalin in Urine (Stephen Merrigan, Kamisha L. Johnson-Davis)....Pages 119-127
The Evolving Landscape of Designer Drugs (Sherri L. Kacinko, Donna M. Papsun)....Pages 129-135
Analysis of Synthetic Cannabinoid Metabolites by Liquid Chromatography-Tandem Mass Spectrometry (Gregory C. Janis)....Pages 137-147
Quantification of Designer Opioids by Liquid Chromatography–Tandem Mass Spectrometry (Sherri L. Kacinko, Joseph W. Homan)....Pages 149-163
Screening Analysis for Designer Stimulants by LC-MS/MS (Piotr Adamowicz, Bogdan Tokarczyk)....Pages 165-180
Drug Screening Using Liquid Chromatography Quadrupole Time-of-Flight (LC-QqTOF) Mass Spectrometry (Jennifer M. Colby, Kara L. Lynch)....Pages 181-190
Alternate Matrices: Meconium, Cord Tissue, Hair, and Oral Fluid (Kendra L. Palmer, Matthew D. Krasowski)....Pages 191-197
Salt-Assisted Liquid-Liquid Extraction of Meconium for Analysis of Cocaine and Amphetamines by Liquid Chromatography-Tandem Mass Spectrometry (Melissa M. Goggin, Gregory C. Janis)....Pages 199-209
Detection of In Utero Cannabis Exposure in Umbilical Cord Tissue by a Sensitive Liquid Chromatography-Tandem Mass Spectrometry Method (Fang Wu, Triniti L. Jensen, Gwendolyn A. McMillin)....Pages 211-222
Quantitation of Ethyl-β-d-Glucuronide in Human Umbilical Cord Tissue by Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS) (Simuli L. Wabuyele, Gwendolyn A. McMillin)....Pages 223-236
Analysis of Drugs in Oral Fluid Using LC-MS/MS (Cynthia A. Coulter, Christine M. Moore)....Pages 237-259
Determination of Cocaine and Metabolites in Dried Blood Spots by LC-MS/MS (Lars Ambach, Christophe Stove)....Pages 261-272
Back Matter ....Pages 273-274