LC-MS in Drug Bioanalysis

✍ Scribed by Aimin Tan, Nadine Boudreau, Ann Lévesque (auth.), Q. Alan Xu, Timothy L. Madden (eds.)

• Publisher: Springer US
• Year: 2012
• Tongue: English
• Leaves: 483
• Edition: 1
• Category: Library

✦ Synopsis

Clinical pharmacology plays an important role in today’s medicine. Due to the high sensitivity, selectivity, and affordability of a mass spectrometer (MS), the high performance liquid chromatography – mass spectrometry (LC-MS) analytical technique is widely used in the determination of drugs in human biological matrixes for clinical pharmacology. Specifically, LC-MS is used to analyze: anticancer drugs antidementia drugs antidepressant drugs antiepileptic drugs antifundal drug antimicrobial drugs antipsychotic drugs antiretroviral drugs anxiolytic/hypnotic drugs cardiac drugs drugs for addiction immunosuppressant drugs mood stabilizer drugs This book will primarily cover the various methods of validation for LC-MS techniques and applications used in modern clinical pharmacology.

✦ Table of Contents

Front Matter....Pages i-xi
Internal Standards for Quantitative LC-MS Bioanalysis....Pages 1-32
Method Development, Validation, and Sample Analysis for Regulated Quantitative Bioanalysis Using LC-MS/MS....Pages 33-66
Impact of Sampling Paper/Cards on Bioanalytical Quantitation via Dried Blood Spots by Liquid Chromatography-Mass Spectrometry....Pages 67-80
Highly Sensitive Pharmaceutical and Clinical Analysis Using Selective Solid-Phase Extraction Coupled to Microflow Liquid Chromatography and Isotope-Dilution Mass Spectrometry....Pages 81-107
Pitfalls of LC-MS/MS in the Clinical Laboratory....Pages 109-126
Therapeutic Drug Monitoring to Support Clinical Pharmacogenomics....Pages 127-141
Liquid Chromatography-Mass Spectrometry for the Determination of Antidepressants and Some of their Major Metabolites in Human Biological Matrices....Pages 143-175
The Analysis of Antipsychotic Drugs in Human Biosamples by LC-MS....Pages 177-195
Therapeutic Drug Monitoring of Targeted Anticancer Therapy. Tyrosine Kinase Inhibitors and Selective Estrogen Receptor Modulators: A Clinical Pharmacology Laboratory Perspective....Pages 197-250
Applications of Mass Spectrometry in Analyses of Steroid Hormones....Pages 251-286
Liquid Chromatography-Mass Spectrometric Analysis of Tropane Alkaloids in Mammalian Samples: Techniques and Applications....Pages 287-347
Analysis of Illicit Drugs in Human Biological Samples by LC-MS n ....Pages 349-398
Use of Matrix Assisted Laser Desorption/Ionization Imaging Mass Spectrometry (MALDI-IMS) in the Development of Novel Small Molecule Drugs....Pages 399-422
A Planar Integrated Micro-mass Spectrometer....Pages 423-465
Back Matter....Pages 467-469

✦ Subjects

Mass Spectrometry; Analytical Chemistry; Pharmacology/Toxicology; Chromatography