𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Layer-specific functional and anatomical MRI of the retina with passband balanced SSFP

✍ Scribed by Eric R. Muir; Timothy Q. Duong

Book ID
102953180
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
932 KB
Volume
66
Category
Article
ISSN
0740-3194

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The retina consists of multiple cellular and synaptic layers and is nourished by two distinct (retinal and choroidal) circulations bounding the retina, separated by an avascular layer. High spatiotemporal resolution, layer‐specific MRI of the retina remains challenging due to magnetic inhomogeneity‐induced artifacts. This study reports passband balanced steady‐state free‐precession (bSSFP) MRI at 45×45×500 μm and 1.6 s temporal resolution to image the mouse retina, overcoming geometric distortion and signal dropout while maintaining rapid acquisition and high signal‐to‐noise ratio. bSSFP images revealed multiple alternating dark‐bright‐dark‐bright retinal layers. Hypoxic (10% O~2~) inhalation decreased bSSFP signals in the two layers bounding the retina, corresponding to the retinal and choroidal vasculatures. The layer in between showed no substantial response and was assigned the avascular photoreceptor layers. Choroidal responses (−25.9±6.4%, mean±SD, n=6) were significantly (P<0.05) larger than retinal vascular responses (−11.6±2.4%). bSSFP offers very high spatiotemporal resolution and could have important applications in imaging layer‐specific changes in retinal diseases. Magn Reson Med, 2011. © 2011 Wiley Periodicals, Inc.

📜 SIMILAR VOLUMES

Layer-specific anatomical, physiological
Layer-specific anatomical, physiological and functional MRI of the retina
✍ Timothy Q. Duong; Machelle T. Pardue; Peter M. Thulé; Darin E. Olson; Haiying Ch 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 873 KB

## Abstract Most retinal imaging has been performed using optical techniques. This paper reviews alternative retinal imaging methods based on MRI performed with spatial resolution sufficient to resolve multiple well‐defined retinal layers. The development of these MRI technologies to study retinal

Evaluation of the anatomical and functio
Evaluation of the anatomical and functional properties of deglutition with various kinetic high-speed MRI sequences
✍ A. Anagnostara; S. Stoeckli; O.M. Weber; S.S. Kollias 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 227 KB

## Abstract We evaluated various fast MR sequences for obtaining anatomical and dynamic functional information during deglutition. Seven healthy volunteers underwent MRI of the oropharynx during swallowing of an oral positive‐contrast agent. Single‐slice imaging was performed in the median sagittal