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Layer-specific anatomical, physiological and functional MRI of the retina

✍ Scribed by Timothy Q. Duong; Machelle T. Pardue; Peter M. Thulé; Darin E. Olson; Haiying Cheng; Govind Nair; Yingxia Li; Moon Kim; Xiaodong Zhang; Qiang Shen


Book ID
102959792
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
873 KB
Volume
21
Category
Article
ISSN
0952-3480

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✦ Synopsis


Abstract

Most retinal imaging has been performed using optical techniques. This paper reviews alternative retinal imaging methods based on MRI performed with spatial resolution sufficient to resolve multiple well‐defined retinal layers. The development of these MRI technologies to study retinal anatomy, physiology (blood flow, blood volume, and oxygenation) and function, and their applications to the study of normal retinas, retinal degeneration and diabetic retinopathy in animal models are discussed. Although the spatiotemporal resolution of MRI is poorer than that of optical imaging techniques, it is unhampered by media opacity and can thus image all retinal and pararetinal structures, and has the potential to provide multiple unique clinically relevant data in a single setting and could thus complement existing retinal imaging techniques. In turn, the highly structured retina with well‐defined layers is an excellent model for advancing emerging high‐resolution anatomical, physiological and functional MRI technologies. Copyright © 2008 John Wiley & Sons, Ltd.


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