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Late relapse with nodular lymphoma after treatment for diffuse non-Hodgkin's lymphoma

✍ Scribed by M. Marazuela; M. Yebra; J. A. Girón; J. L. Menéndez; J. A. Vargas; P. España; M. Garcia-Font; A. Durántez

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
535 KB
Volume
67
Category
Article
ISSN
0008-543X

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✦ Synopsis

Histologic conversion from a low-grade non-Hodgkin's lymphoma (NHL) into a more aggressive histologic pattern is a common, well-documented event in NHL. The converse phenomenon, appearance of a low-grade, follicular NHL after treatment for diffuse, intermediate, or high-grade NHL, has only recently been recognized. The clinical, morphologic, and immunologic features of a patient in whom relapse with an indolent nodular lymphoma was noticed after combination chemotherapy for diffuse lymphoma are presented. Immunologic markers at presentation and relapse were similar. Other previously reported cases are reviewed. Implications for diagnosis and therapy as well as the pathogenesis of this unique form of conversion are discussed.

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✍ Carine Kirkove; Adrian R. Timothy 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 319 KB

## Abstract The prognosis of relapsing Hodgkin's disease (HD) and high grade aggressive non‐Hodgkin's lymphoma (NHL) is generally poor since many of these patients fail to respond to second line chemotherapy. Radiation therapy has been reported as an effective but seldom used, alternative treatment