## Abstract ## Background Neoadjuvant chemoradiotherapy does not alter anal sphincter preservation or postoperative complications compared with short-course radiotherapy alone in patients with clinical stage T3 or T4 resectable rectal cancer. The aim of this study was to compare survival, local co
Late adverse effects of short-course preoperative radiotherapy in rectal cancer
✍ Scribed by J. Pollack; T. Holm; B. Cedermark; D. Altman; B. Holmström; B. Glimelius; A. Mellgren
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 110 KB
- Volume
- 93
- Category
- Article
- ISSN
- 0007-1323
- DOI
- 10.1002/bjs.5525
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Background. From 1980 to 1987, 849 patients with clinically resectable rectal adenocarcinoma were randomized into a controlled clinical trial to evaluate the role of preoperative radiotherapy. Methods. Patients were given either 25 Gy during 5 to 7 days before surgery or underwent surgery alone. R
## BACKGROUND. Adjuvant preoperative radiotherapy of patients with primary rectal carcinoma improves local control and survival, but also may increase the risk of early postoperative morbidity and mortality. I n addition, the possible late adverse effects of this treatment are largely unknown. METH