Laser microprobe mass spectrometry of selected compounds directly from normal phase high-performance thin-layer plates

✍ Scribed by R.W. Finney; H. Read

• Book ID: 104144559
• Publisher: Elsevier Science
• Year: 1989
• Tongue: English
• Weight: 424 KB
• Volume: 471
• Category: Article
• ISSN: 1873-3778
• DOI: 10.1016/s0021-9673(00)94186-4

✦ Synopsis

Direct analysis of high-performance

thin-layer chromatography (HPTLC) plates by laser microprobe mass spectrometry has been demonstrated. A series of general organics and ionic surfactants were examined as reference materials and after application to normal-phase HPTLC plates. Spectra were generated, containing structurally significant ions and a contribution from the silica chromatography medium. After chromatography in a solvent system, spectra were weak but included sufficient compound-specific ions to permit structural confirmation. The identification of total unknowns by this means alone would at present be speculative but, supplemented by visualisation reagents and known chromatographic reference points, valuable information can be gained.