Large-ring lactones by internal ketophosphonate cyclizations
β Scribed by Stork, Gilbert; Nakamura, Eiichi
- Book ID
- 120499124
- Publisher
- American Chemical Society
- Year
- 1979
- Tongue
- English
- Weight
- 298 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0022-3263
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π SIMILAR VOLUMES
W-Bromoacetoxy-and W-(a-bromopropionyloxy) aldehydes were cyclized by SmI2 giving 8-to 14-membered ring @-hydroxy lactones in excellent yields. Recent synthetic elaborations in the field of macrolides have prompted the development of numerous useful lactonization methods. 2) However, few of them are
The reaction of allylic halides with nickel carbonyl is a very useful method for the formation of carbon-carbon bonds (e.g. equation 1). 132 This reaction has been applied to the 2R Ni(C0J4 Br intramolecular coupling, or cyclization,of various allylic dihalides. 394 Herein we describe a further ext