Preparation of Medium-Ring Lactones and Lactams by Electrophilic Cyclizations
✍ Scribed by Homsi, Fadi; Rousseau, Gérard
- Book ID
- 121347895
- Publisher
- American Chemical Society
- Year
- 1998
- Tongue
- English
- Weight
- 58 KB
- Volume
- 63
- Category
- Article
- ISSN
- 0022-3263
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
W-Bromoacetoxy-and W-(a-bromopropionyloxy) aldehydes were cyclized by SmI2 giving 8-to 14-membered ring @-hydroxy lactones in excellent yields. Recent synthetic elaborations in the field of macrolides have prompted the development of numerous useful lactonization methods. 2) However, few of them are
## Abstract For Abstract see ChemInform Abstract in Full Text.
The intramolecular cyclizations of oxazolidinones with carbanions adjacent to sulfones, sulfoxides and phosphonates proceed in high yields to obtain functionalized γ and δ lactams. The chiral oxazolidinone precursors can be readily synthesized from commercial amino acids. The lactams from this study