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Langerhans’ cell histiocytosis and haemophagocytic lymphohistiocytosis in an elderly patient

✍ Scribed by D Ioannidou; K Krasagakis; J Panayiotidis; M Stefanidou; M Alexandrakis; A Tosca

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
133 KB
Volume
17
Category
Article
ISSN
0926-9959

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✦ Synopsis

ABSTRACT

We present a case of a 78‐year‐old man suffering from a chronic psoriasiform eruption, with rapid deterioration over the previous 8 weeks. Langerhans’ cell histiocytosis with skin and bone involvement was diagnosed, and there was evidence of liver and lung dysfunction. The patient was treated with prednisolone and etoposide, and initially experienced a partial improvement. Three weeks later, haemophagocytic lymphohistiocytosis and subsequently a large pulmonary abscess with sepsis attributed to opportunistic gram‐negative enterobacteriaceae Serratia marcescens developed, and the patient died. The present case of Langerhans’ cell histiocytosis is of particular interest because of the previously unreported development of haemophagocytic lymphohistiocytosis in the elderly population.

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