Senile EBV-associated B-cell lymphoproliferative disorder of prepatellar bursa in an elderly patient with multifocal urate arthropathy
✍ Scribed by Susanna Mueller; Thomas Aigner; Jochen Haag; Rene Schwarz; Gerald Niedobitek
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 294 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0278-0232
- DOI
- 10.1002/hon.814
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
We report a case of an EBV‐associated high grade B‐cell lymphoproliferative disorder occurring in the synovial membrane of an elderly patient with gout arthropathy. The EBV‐infected B‐cells displayed a pattern of viral gene expression (EBNA2^+^/LMP1^+^) typically seen during primary EBV‐infection and in lymphoproliferations occurring in immunosuppressed individuals. This case conforms to senile EBV‐associated lymphoproliferative disorders previously reported only in Japanese patients. We suggest that an impaired EBV‐specific T‐cell immunity, local or systemic, may play a role in the development of this disorder and that chronic diseases such as gout may be contributing factors. Copyright © 2007 John Wiley & Sons, Ltd.