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Langerhans cell histiocytosis: A reactive or neoplastic disorder?

✍ Scribed by Zelger, Bernhard


Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
36 KB
Volume
37
Category
Article
ISSN
0098-1532

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A study of 47 well-documented patients with Langerhans cell histiocytosis (LCH) showed a slight female preponderance, with onset as late as the ninth decade. The skin was the commonest site of presentation, but pulmonary and bone involvement was frequent. Patients with single-site disease did best.

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Background. Treatment of multisystem Langerhans cell histiocytosis (LCH) remains difficult. Various regimens of single and multiagent chemotherapy have been used, but a significant proportion of patients fail to respond to treatment. Procedure. We have evaluated the use of cyclosporine A (CSA) in a