As Cancer commemorates 50 years of continuous publication, this article is one of a series of summaries on the current status of some of the oncologic issues reported in the first volume in 1948.
Landmark trials in endocrine adjuvant therapy for breast carcinoma
β Scribed by William Gradishar
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 78 KB
- Volume
- 106
- Category
- Article
- ISSN
- 0008-543X
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## Abstract ## BACKGROUND In the current study, the authors describe the M. D. Anderson experience with adjuvant systemic therapy in male breast carcinoma patients. ## METHODS A total of 156 men with a diagnosis of breast carcinoma registered and were treated at the M. D. Anderson Cancer Center
Based on estrogen receptor (ER) status and menopausal status, operable breast cancer (International Union Against Cancer [UICC] Stage I, II, and III) patients were randomized for adjuvant endocrine therapy, chemotherapy, and chemoendocrine therapy, and the effects on the disease-free survival (DFS)
## Abstract ## BACKGROUND Traditional nonparametric statistical methods do not provide a quantitative measure of the lifetime benefit from adjuvant therapy. This deficiency makes it difficult to determine the longβterm difference in impact between the two treatment arms of a clinical trial. ## ME