Lamivudine response of IgM anti-HBc chronic hepatitis B: authors' reply
β Scribed by J.-J. Chen; S.-L. Tsai
- Book ID
- 108604564
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 46 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0269-2813
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## Abstract Because of widely differing reports on the significance of IgM antiβHBc in chronic hepatitis B virus (HBV) infection, paired sera and liver biopsies from 49 patients with chronic HBV infection were analysed for serum IgM antiβHBc, HBsAg titre, HBeAgiantiβHBe, HBV DNA, serum aspartate tr
IgM anti-HBc was measured by radioimmunoassay in se~rially collected serum samples during 20 acute exacerbations which developed in 14 patients with anti-HBe paeitive chronic type B hepatitis. IgM anti-HBc became @the in 12 of the 14 (86%) patients and in 18 of the 20 (90%) exacerbations, and elevat
The time sequence, relative reactivity, and persistence of anti-HBc IgM were assessed in patients with HBsAg-positive viral hepatitis. A solid-phase immunoassay was developed using the IgM capture procedure with anti-p-coated polystyrene beads. HBcAg was purified from serum Dane particles and used a
Numerous tests to detect anti-HBc IgM have been developed and shown to have different degrees of sensitivity and specificity. One of these assays, Corzyme@-M (Abbott Laboratories, North Chicago, Ill.), recently became commercially available. The present study was undertaken to evaluate the clinical