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IgM anti-HBc in anti-HBe positive chronic type B hepatitis with acute exacerbations

✍ Scribed by Kazuhiko Koike; Shiro Iino; Kiyohiko Kurai; Keiji Mitamura; Yasuo Endo; Hiroshi Oka

Publisher
John Wiley and Sons
Year
1987
Tongue
English
Weight
408 KB
Volume
7
Category
Article
ISSN
0270-9139

No coin nor oath required. For personal study only.

✦ Synopsis

IgM anti-HBc was measured by radioimmunoassay in se~rially collected serum samples during 20 acute exacerbations which developed in 14 patients with anti-HBe paeitive chronic type B hepatitis. IgM anti-HBc became @the in 12 of the 14 (86%) patients and in 18 of the 20 (90%) exacerbations, and elevation of IgM anti-HBc which was believed to be significant was also observed in the remaining two patients. In most of the patients who also had determinations of serum hepatitis B virus DNA, the hepatitis B virus DNA became positive. These results suggest that ALT elevation in anti-HBe positive chronic type B hepatitis is associated with active replication of hepatitis B virus. It is considered to be useful to measure IgM anti-HBc for the purpose of identifying the cap888 of ALT elevation in anti-HBe positive chronic type B hepatitis.

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