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Lamivudine and Famciclovir resistant hepatitis B virus associated with fatal hepatic failure

✍ Scribed by Anna Ayres; Angeline Bartholomeusz; George Lau; Kui-Chan Lam; Jia-Yee Lee; Stephen Locarnini


Book ID
117769630
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
324 KB
Volume
27
Category
Article
ISSN
1386-6532

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Several mutations (V521L, P525L, L528M, T532S, and V555I) in the gene for hepatitis B virus (HBV) polymerase have been identified in HBV isolated from patients that displayed break-through viremia during famciclovir treatment. To determine whether these mutations cause phenotypic resistance to famci