Lambert–Eaton syndrome with large-cell neuroendocrine carcinoma of the lung

✍ Scribed by Christian Grommes; David C. Preston; Zaid Al-Kadhimi; Amer Alshekhlee

• Publisher: John Wiley and Sons
• Year: 2008
• Tongue: English
• Weight: 295 KB
• Volume: 37
• Category: Article
• ISSN: 0148-639X
• DOI: 10.1002/mus.21032

✦ Synopsis

Abstract

Lambert–Eaton syndrome (LES) is an immune‐mediated disorder of the presynaptic neuromuscular junction due to the blocking effect of the voltage‐gated calcium channel (VGCC) antibodies. Small‐cell lung cancer (SCLC) is the most common cause of LES. We report an unusual case of LES associated with large‐cell neuroendocrine carcinoma (LCNEC) of the lung. In this case, clinical symptoms of LES predated the diagnosis of LCNEC by 6 years. After tumor resection, the patient experienced clinical and electrophysiological improvement. In addition, he had a decrease in VGCC antibody titer from 130 to 80 pmol/L. The onset of LES can be prolonged, and tumor surveillance should continue in these cases. Muscle Nerve 37: 786–789, 2008