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Lactacystin, a Specific Inhibitor of the Proteasome, Induces Apoptosis in Human Monoblast U937 Cells

โœ Scribed by S. Imajohohmi; T. Kawaguchi; S. Sugiyama; K. Tanaka; S. Omura; H. Kikuchi


Book ID
115577793
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
630 KB
Volume
217
Category
Article
ISSN
0006-291X

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Lactacystin, a specific inhibitor of the
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The multicatalytic protease complex or proteasome is a fundamental nonlysosomal tool that the cell uses to process or degrade proteins at a fast rate through the ubiquitin and ATP-dependent proteolytic pathway. Examples of these important proteins include the tumor suppressor protein p53, various cy