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The proteasome-specific inhibitor lactacystin blocks presentation of cytotoxic T lymphocyte epitopes in human and murine cells

✍ Scribed by Vincenzo Cerundolo; Adam Benham; Veronique Braud; Siddhartha Mukherjee; Keith Gould; Beatrice Macino; Jacques Neefjes; Alain Townsend

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
635 KB
Volume
27
Category
Article
ISSN
0014-2980

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## Abstract EBV‐infected cells and EBV‐associated tumors may evade CTL recognition by defective antigen processing, resulting in poor presentation of CTL epitopes. Since the proteasome is the major source of MHC class I–presented peptides, we analyzed the effect of proteasome inhibitors on the expr