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Lack of susceptibility of transgenic mice carrying the human c-Ha-ras proto-oncogene (rasH2 mice) to phenolphthalein in a 6-month carcinogenicity study

โœ Scribed by Takatoshi Koujitani; Kazuo Yasuhara; Toshimi Usui; Tatsuji Nomura; Hiroshi Onodera; Hisayoshi Takagi; Masao Hirose; Kunitoshi Mitsumori


Book ID
117466443
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
540 KB
Volume
152
Category
Article
ISSN
0304-3835

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To determine if hemizygous transgenic mice carrying the human c-Ha-ras gene (CB6F1-Tg Hras2 mice (Hras2 mice)) are susceptible to the carcinogenic potential of known murine carcinogens, male and female Hras2 mice and their non-transgenic CB6F1 littermates (non-Tg mice) were each given a single intra