Lack of prognostic value of T-, B- and null-lymphocytes in adult acute leukemia

✍ Scribed by Jehn, U. ;Wachholz, K. ;Kern, D. ;Hölzel, D.

• Publisher: John Wiley and Sons
• Year: 1983
• Tongue: English
• Weight: 767 KB
• Volume: 11
• Category: Article
• ISSN: 0098-1532
• DOI: 10.1002/mpo.2950110207

✦ Synopsis

The distribution of T-, B-and null-lymphocytes was studied in the peripheral blood of 38 adult patients with acute nonlymphocytic leukemia (ANLL) and 15 with acute lymphocytic leukemia (ALL) at first diagnosis, during induction treatment, and in remission. Thirteen ANLL and 9 ALL patients were followed until relapse and during reinduction therapy. T-and Bcells were detected by specific membrane marker. The pre-and posttreatment pattern of lymphocyte subpopulations was analyzed to determine their prognostic significance for remission incidence, remission du-ration, and survival. It was observed that in both types of leukemia, Tcells are more affected by the leukemic process and cytostatic drugs than Bcells. Nonresponding patients possibly have a reduced potential for recruiting precursor T-and Bcells. At first diagnosis, no significant correlation was found between pre-or posttreatment variables and prognosis. At relapse, ANLL patients had a longer second remission when a high proportion of Bcells was found; ALL patients with a high lymphocyte count before and after treatment, experienced longer survival.