Lack of Phospholipase D Activity in Chromaffin Cells: Bradykinin-Stimulated Phosphatidic Acid Formation Involves Phospholipase C in Chromaffin Cells but Phospholipase D in PC12 Cells
โ Scribed by John Purkiss; Richard A. Murrin; P. Jane Owen; Michael R. Boarder
- Book ID
- 111176310
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 386 KB
- Volume
- 57
- Category
- Article
- ISSN
- 0022-3042
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Phospholipase D (PLD) is activated in mammalian cells in response to a variety of growth factors and may play a role in cell proliferation. Lysophosphatidic acid (LPA) is a bioactive metabolite potentially generated as a result of PLD activation. Two human prostate cancer cell lines, PC-3 and LNCaP,
## Abstract We have previously reported that endothelinโ1 stimulates phospholipase Cโinโduced hydrolysis of phosphatidylinositolโ4, 5โbisphosphate, Other signal transduction pathways that hydrolyze alternative phospholipids through phospholipase D may also mediate endothelinโstimulated cellular res