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Lack of mutation at p16INK4A gene but expression of aberrant p16INK4A RNA transcripts in human ovarian carcinoma

โœ Scribed by Seong-Il Suh; Jae-We Cho; Won-Ki Baek; Min-Ho Suh; Dennis A Carson


Book ID
117466474
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
449 KB
Volume
153
Category
Article
ISSN
0304-3835

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The p16 INK4A gene, which encodes the cell-cycle regulatory protein cyclin-dependent kinase 4 inhibitor, is a putative tumor-suppressor gene. We examined p16 gene alterations in 30 primary ovarian cancers and 11 ovarian cancer cell lines. Five of the primary cancers (16.7%) had lost both p16 INK4A g